NIOD

Renude

dark circles

eye bags

undereye wrinkles

I have chosen this active-loaded eye serum as your daily eye product to target all undereye concerns: fine lines, dark circles and eye bags.

acetyl tetrapeptide

Many peptides function as anti-ageing ingredients in skincare, due to their ability to fit specific receptors in the body to trigger anti-ageing responses. This includes mechanisms like collagen production, cell regeneration or even blocking muscle contractions to smooth expression lines. Peptides are made up of amino acids, and are unique in shape, with a huge variety available to target specific responses in the body.

L-ascorbic acid is Vitamin C in its purest form, and the active form required by the body to result in the many skin skin benefits of Vitamin C. The issue with L-ascorbic acid is in the delivery, as it is very unstable in water, and needs a pH 4 or below for it to penetrate the skin. That being said, when it can be stabilised in a formula and is able to penetrate the skin, it provides the highest potency of any form of Vitamin C currently available.

ascorbic acid

Vitamin C has many skin benefits, including its action as an antioxidant, to neutralise free radicals (reactive molecules with an unpaired electron), preventing them from causing damage to cells within the body. Vitamin C is also involved in the collagen-production process, so provides anti-wrinkle activity through this mechanism. Lastly, Vitamin C inhibits the enzyme tyrosinase, which is involved in melanin-synthesis, and can therefore visibly reduce areas of hyperpigmentation in the skin.

Ascorbyl Glucoside is a water-soluble derivative of Vitamin C. This derivative was created to provide improved stability and skin penetration vs. ascorbic acid alone. It is still unclear how well ascorbyl glucoside is converted into ascorbic acid (the active form of Vitamin C) within the body, but some of it will be lost during this conversion, making this less potent, and therefore requiring higher levels in the formulation in order to achieve great results.

ascorbyl glucoside

epigallocatechin gallatyl glucoside

Epigallocatechin Gallate (EGCG) is a catechin found naturally in abundance within green tea. It has a number of skin benefits, firstly as a powerful antioxidant, meaning it can neutralise free radicals before they can cause damage to skin cells. Studies have also shown it to encourage the production of the skin’s natural moisturising factor (NMF), in turn increasing the skin’s ability to retain moisture, which results in more hydrated, plump, smoother skin. There is some research to show that EGCG can also reduce visible hyperpigmentation by inhibiting the production of melanin in the skin.

heptapeptide-15 palmitate

Niacinamide, also known as Vitamin B3 and Nicotinamide, has many skincare benefits. Firstly, it regulates sebum production in the skin, which in turn reduces blemishes and visible pore size. It also reduces facial redness by improving microcirculation, which means moving the blood inside the capillaries away from the face to reduce visible redness. It also has the ability to strengthen the natural lipid barrier of the skin by encouraging ceramide production (the building blocks which seal our skin cells together), which in turn increases the hydration within the epidermis. Lastly, niacinamide works to help reduce hyperpigmentation by blocking melanin from being deposited on the skin cells.

niacinamide

oligopeptide

palmitoyl decapeptide

palmitoyl heptapeptide

palmitoyl hexapeptide

palmitoyl nonapeptide

palmitoyl tetrapeptide

palmitoyl tripeptide

pentapeptide

Sodium hyaluronate is the sodium salt of hyaluronic acid (a polysaccharide which occurs naturally in the body), created to improve the ingredient stability. It works as an extremely powerful humectant, able to attract 1000x its own weight in water, to immediately plump and hydrate the area it is applied to. The body’s own production of hyaluronic acid slows with age, so supplementing this ingredient in topical formulations helps to support the skin’s natural moisture-binding, anti-ageing mechanisms.

sodium hyaluronate

Hyaluronic acid is a polysaccharide which occurs naturally in the body. Hyaluronic acid works as an extremely powerful humectant, able to attract 1000x its own weight in water, to immediately plump and hydrate the area it is applied to. The body’s own production of hyaluronic acid slows with age, so supplementing this ingredient in topical formulations helps to support the skin’s natural moisture-binding, anti-ageing mechanisms.

Superoxide dismutase is an enzyme produced naturally in the body, specifically to break down the free radical superoxide (an oxygen with an excess electron and thus a negative charge). It is considered to be the body’s most important antioxidant and works by catalysing the conversion of superoxide, into elemental oxygen (O2) and hydrogen peroxide (H2O2), a process known as dismutation. This action is part of the body’s natural anti-ageing mechanism, so including this ingredient in skincare supports this natural protection process.

superoxide dismutase

A hyper-concentrated bio-serum for the eye contour, FECC combines 28 clinical technologies to target many signs of under-eye and above-eye aging in one treatment—borrowing from advanced biotechnology, polyphenol technology, next-generation cyclic peptide technologies, marine science and modern drone delivery mechanics. This single treatment is able to target visible aging (both upper eyelids and lower eyelids) including the looks of dynamic lines, static lines, fine superficial under-eye lines (those not targeted by SNARE-target injections), loss of elasticity (especially upper-eyelids), dark circles, eye bags and textural unevenness with positive visible results starting within 3 days and improving into 8 weeks with continued use.

FECC contains 28 complex approaches to fight visible aging of the eye contour. This abstract highlights the most novel of these approaches.

HA AND COLLAGEN TECHNOLOGIES
Fibroblast Drone
Perhaps a most advanced skin technology available, this suspension contains extraordinary capsules that secure a pro-HA peptide within a polymer core that is surrounded by a Heptapeptide to specifically bind to targets before release, exponentiating delivery and effectiveness to an accuracy level previously impossible. No technology today delivers the visible filling activity of this truly complex system to support Hyaluronic Acid.
Bio-Yeast HA Pre-Cursor (also found in NIOD MMHC)
Contains oligomers of acetylated glucuronic acid derived from biofermentation acting as HA precursors.
Methyl-Glucoside-6-Phosphate (MG6P)
Perhaps one of the most advanced peptide complex technologies of today, this active improves the looks of firmness, density and elasticity in 11 days or less.
Enzyme-Reacted Glucosamine Amide HA Pre-Cursor (also found in NIOD MMHC)
Highly advanced compound is derived by enzymatic phosphorylation of N-acetyl-glucosamine through a green chemistry process acting as a secondary precursor of HA.
Full-Spectrum Fractions of Nature-Identical Hyaluronic Acid
Not to be mistaken for any form of hyaluronic acid—low- or high- molecular weight—these two forms of actual fractions of hyaluronic acid—not salts of hyaluronic acid used in nearly every topical HA product for a different purpose—these two technologies offer both short- and long-term visible filling of the looks of wrinkles while improving the look of elasticity.
Darutoside Complex
A plant-technology bio-derivative offers improvement in the looks of both upper- and lower-eyelid elasticity while reducing the appearance of folds in the upper eyelids specifically—an area previously not targeted by topical technologies.
Other Technologies in This Category: Third-generation Matrixyl peptide and Persian Silk Tree bio-technology.
EXPRESSION TECHNOLOGIES
Neuron Drone
This second drone technology encapsulates the well-studied Palmitoyl Hexapeptide, highly-effective against the look of expression lines, within a polymer layer that is then surrounded by a Palmitoyl Heptapeptide to behave like a drone for specific binding to targets, reducing peptide wastage by 90% as a direct result of this specific targeting mechanism.
SNAP-25 Pentapeptide-18 Complex
The next-generation of the famed technology, Acetyl Hexapeptide-8 (commonly known as Argireline), extends this peptide with a novel Pentapeptide-18 to reduce the signs of expression lines developed by extensive small-twitch muscle contractions, offering a 100% further efficacy index over Argireline alone.
Novel Arginine-Sustained Acetyl-Hexapeptide-30
A more advanced form of this modern peptide which was the first-ever to fight signs of ageing as a result of facial expressions.
Other Technologies in This Category: Walgerin-1 tripeptide technology, snail venom mimetic technology.
UNEVEN PIGMENTATION TECHNOLOGIES
Marigold/Yeast Ferment Bio-Complex
This biotechnology has shown up to a 94% positive response in reducing both the look of dark circles and feelings of sensitivity.
Bio-Tech Superoxide Dismutase Hydrolyzed Peptide Complex
This complex offers indirect inclusion of SOD, the body's own most important oxyradical fighting mechanism, in a first-ever stable form.
Oleuropein Zinc Salt Bio Complex
It was until recently thought that inefficient circulatory mechanisms around the eyes are the only cause of dark circles—other than the shadows created by hollowness defined by bone and fat structures. However, it has now been shown that imbalanced melanin formation also contributes to dark circles. To address this issue, typical skin-lightening technologies cannot be used since the objective is to balance and even the pigmentation and not lighten the skin just under the eye areas on a continuing basis. This superb polyphenol complex rebalances the look of skin pigmentation to its natural state. This approach does not target melanocyte function or melanin, allowing ongoing use without possibility of unintended visible lightening.
Other Technologies in This Category: Propyl Gallate, Gallyl Glucoside, Epigallocatechin Gallatyl Glucoside—target looks of both dark circles and redness.
FLUID RETENTION TECHNOLOGIES
Angiotensin I Converting Enzyme (ACE) Target Tetrapeptide
A complex peptide system, this technology reduces the look of under-eye eye bags within 15 days with continued use.
Silanetriol-Delivery Vitamin F Complex
Fast-acting plant-silicones delivery technology reduces the look of eye bags and, as a positive side effect, reduces the look of discolouration under the eyes.
Algae-Harvested Sulphated Polysaccharides
One of the most advanced form of marine technology today, this complex improves the look of resiliency and reduces the look of eye bags simultaneously through shared mechanisms of action.
Other Technologies in This Category: Niacinamide, Fraxinus Excelsior Bark Extract.
REGENERATION TECHNOLOGIES
Hyaluronic Acid Oligomer
Truly a most unique approach that uses a form of hyaluronic acid—which is ordinarily used to lubricate the skin—instead conditioned to algin with visible renewal without the inflammation and irritation associated with low-pH acids and other forms of peeling. (Side note: one of the very unique side observations about this technology is that its stability is entirely from its extremely small size that disallows outside interaction with it.)

redness

I've selected this soothing milky serum for your routine to reduce redness in the skin. It includes neuropeptides and bio-active glucosides to regulate sensory responses, reduce symptoms of irritation whilst evening out any skin blotchiness. Barrier-supporting lipids and antioxidants add further skin support.

Derived from plants, with the ability to soothe the skin by sending signals to the relevant cells to regulate any inflammatory response. It also works to even out skin tone and blotchiness.

Bio-active glucosides

Ceramides are long chains of lipids, which occur naturally within the epidermis. Their function is to hold the skin cells together by creating a barrier against water-loss from the inside-out, and external aggressors from the outside-in. They make up almost 50% of our skins composition, but they can be depleted by UV, free radicals & pollution, and their production also naturally slows with age. This leads to an impaired skin barrier, which results in dry, rough skin with more visible wrinkling and redness. Applying ceramides topically can increase the levels of ceramides in the epidermis, and therefore supports the natural healthy functioning of the skin.

ceramides

An antioxidant and anti-inflammatory plant extract which has been shown to balance the pH of the skin, keeping the natural lipid barrier functioning at it’s best and therefore providing protection against environmental stressors.

Golden-Eye Grass Complex

A plant polyphenol that occurs naturally in the skin of citrus fruits, this works to calm reactive skin as well as reduce associated redness.

Naringenin Chalcone

Sodium PCA is the sodium salt of pyrrolidone carboxylic acid (PCA), which is found naturally in the body, and in the skin’s natural moisturising factor (NMF). PCA acts as a humectant, meaning it draws water to it, plumping and hydrating the area. The skin’s NMF ensures adequate hydration of the stratum corneum, which also works to support the overall barrier function of the skin, regulating trans-epidermal water loss (TEWL). Including Sodium PCA in skincare supports this natural mechanism of the skin.

sodium pca

Natural moisturising factor (NMF) is a substance produced by the body, made up of minerals, lactate, urea, amino acids & humectants, which coats the surface skin cells to keep them moisturised. NMF increases the skin’s ability to retain moisture, which results in more hydrated, plump, smoother skin.

This natural berry is high in antioxidants, to help protect against free radical damage, and also has anti-inflammatory properties to soothe and calm.

tasmannia lanceolata fruit/leaf extract

Modulating Glucosides is a concentrated emulsion to target signs of skin sensitivity, of discomfort and of irritation. This serum reduces the looks of redness, of itching and of irritation, while helping to target stinging sensations. The formula respects skin integrity and supports hydration, skin barrier and general dermal repair.

dehydrated skin

dull skin

fine lines

ultra dry skin

I have chosen this ultra-hydrating, lightweight formula for you to support your skin's natural barrier to address dryness and improve overall skin texture and radiance.

arginine

disodium acetyl glucosamine phosphate

Humectants are hydrophilic (water-loving) ingredient type that are able to attract water towards them via charges between the molecules. They are therefore brilliant hydrators, and are able to plump out fine lines and wrinkles via surface hydration to provide an anti-ageing effect.

hyaluronic acid

hydrolyzed sodium hyaluronate

myristoyl nonapeptide

Sodium Butyroyl Hyaluronate is a derivative of Hyaluronic acid (a polysaccharide which occurs naturally in the body), which has been modified to add a lipophilic (oil-loving) part for better skin penetration. The supplier also has research to show that this derivative is more resistant to being broken down in the body vs. Hyaluronic acid, so the effects should last longer on the skin.


sodium butyroyl hyaluronate

Sodium Hyaluronate crosspolymer is a modified version of Hyaluronic acid, with additional polymers added to it to slow skin penetration, keeping it in the upper layers of the epidermis for longer to provide surface hydration.

sodium hyaluronate crosspolymer

MMHC2 is the second generation of MMHC. The formula offers a multi-dimensional approach to topical hyaluronic supplementation by combining 15 forms of hyaluronic compounds, hyaluronic precursors and a hyaluronic support technology in a peptide-charged delivery system. It offers water-based hydration and helps skin surface look plump, elastic, comfortable and uniform.

Amongst the 15 hyaluronic compounds is an extremely rare direct form of hyaluronic acid. Almost universally in the world of beauty, the term "hyaluronic acid" is used loosely to refer to "sodium hyaluronate" which is the sodium salt of hyaluronic acid. When brands refer to "hyaluronic acid" in their information and marketing materials, in almost every case the reference is to forms of "sodium hyaluronate" which appears in the ingredient listing of the products. While several sodium salt forms of hyaluronic acid are included in MMHC2, the formula also includes 1.0% direct hyaluronic acid which appears as "hyaluronic acid" in the ingredient listing. This inclusion is exceptionally rare for a broad range of formulation and commercial reasons. Direct hyaluronic acid offers pro-repair support far beyond basic water hydration that sodium hyaluronate offers, resulting in improvements to the elastic appearance and the general healthy look of skin.

uneven texture

I've chosen this non-acid precursor as a super gentle formula to add into your routine, which will help to resurface the skin without any of the irritation sometimes associated with acid exfoliants.

Bisabolol is a naturally-occurring active found in the chamomile plant, although this can also be created synthetically. It’s key properties are as an anti-inflammatory and soothing agent, with some studies also showing it to have a brightening effect on the skin. Bisabolol is also a rich source of Panthenol (Vitamin B5), which acts as a humectant, meaning it draws water molecules towards it to plump and hydrate the area. Studies have also shown that bisabolol can enhance the penetration of other actives into the skin, so is great when used in combination with other actives designed to work at the basal layer of the epidermis, or in fact the dermis.

bisabolol

pseudoalteromonas exopolysaccharides

Algae is an incredibly interesting natural ingredient source. It is essentially an underwater plant, designed to get its food from sunlight, much like any other plants, although from much more challenging conditions. There are many types of algae (kelp, laminaria, microalgae), but in general in all its forms it acts as a powerful antioxidant, protecting from free radical damage, as well as being able to hydrate the skin and deliver naturally-occurring vitamins into the skin.

NAAP is a non-acidic alternative to acid-based epidermal resurfacing. Instead of using direct acids like AHA/BHA or retinoids that are common in skincare, NAAP uses fermentation bio-derivatives and amino isolates that act as precursors to skin-compatible acids, encouraging visible radiance and visible surface regularity without the redness and inflammation associated with acids. NAAP was found non-irritating in an independent Single 48-hr Patch Test.

barrier support

enlarged pores

I have chosen this ultra gentle serum to encourage a mild exfoliation process of the skin, without causing any irritation.

Lactococcus Ferment Lysate is a post-biotic ingredient derived from Gram-positive bacteria, Lactococcus lactis. It is used in skincare for its ability to increase the speed of epidermal growth, leading to a thicker stratum corneum (outermost layer of the skin), and in turn better barrier function. This is seen as healthier-looking, more hydrated and supple skin.

lactococcus ferment lysate

Probiotics can be defined as living bacteria which are good for the skin, and are useful to include in skincare formulations in order to populate a healthy microbiome (the ecosystem of bacteria on the skin). A diverse breadth in the strains of bacteria living on the skin results in a healthy microbiome, and some early research has linked certain imbalances in this microbiome to skin conditions such as acne, ezcema and psoriasis.

NAAP is a non-acidic alternative to acid-based epidermal resurfacing. Instead of using direct acids like AHA/BHA or retinoids that are common in skincare, NAAP uses fermentation bio-derivatives and amino isolates that act as precursors to skin-compatible acids, encouraging visible radiance and visible surface regularity without the redness and inflammation associated with acids. NAAP was found non-irritating in an independent Single 48-hr Patch Test.

A suspension of probiotic bacteria purified through lysis acts as a precursor of skin-compatible natural acids.
Two forms of amino isolates mimic the visible surface-regularizing action of retinoids without any presence of retinoids or related acids.
A bio-ferment oligopeptide offers better exfoliation than alpha hydroxyl acids without irritation or inflammation.
A highly-purified natural levomenol offers surface barrier support, hydration and comfort.
A marine-derived exopolysaccharide increases water-retention capacity—essential with enhanced skin turnover.

NIOD

Products by NIOD

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